Whether Association Evidence Can Be Combined Across Cohorts

Use meta-analysis to pool compatible association rows across cohorts or studies.

• inputs: summary-mode PolyGeniusAssociations objects
• rows must represent the same estimand and effect scale

pooled <- associate$meta(
  ROSMAP = rosmap.assoc,
  ACT = act.assoc,
  method = "random"
)

What comes back

A meta-analysis PolyGeniusAssociations object with pooled estimates, standard errors, confidence intervals, p-values, and study counts.

Plotting

visualize$associations$forest(pooled) visualize$associations$heatmap(pooled)

Open the meta-analysis guide