Case studies

The following section contains the code for the full analysis workflows presented in the PolyGenius manuscript:

Case study 1: Generating and prioritizing PGS models

This scenario illustrates a common PolyGenius workflow for Alzheimer’s disease (AD): generate a set of candidate PGS models from one GWAS source, and benchmark them in…

Case study 2: Leveraging PGS models for downstream biological inference

In the following case study we shows the next step after model selection: taking a PGS model and using it for downstream biological inference in an independent cohort.…

Case study 3: Scalable multi-trait polygenic analysis with cross-cohort meta-analysis

PolyGenius enables users to go furher than small-scale targeted PGS analysis, enabling the joint generation, computation, and association of thousands of PGS models, and to…