associate$mediation

Mediation analyses for PolyGeniusData

Description

associate$mediation() estimates total, direct, and indirect effects for a specified exposure-mediator-outcome triplet resolved from a PolyGeniusData object.

Summary mode returns a PolyGeniusAssociations object using the mediation schema. Model mode returns the raw fitted mediator model, outcome model, and backend mediation object.

Usage

`associate$mediation`(data, exposure, mediator, outcome, covariates = NULL, outcome.model = c("auto", "lm", "glm"), method = c("natural.effects", "baron.kenny"), weights = NULL, output = c("summary", "models"), ...)

Arguments

data

A PolyGeniusData object.

exposure

Unquoted exposure expression.

mediator

Unquoted mediator expression.

outcome

Unquoted outcome expression.

covariates

Optional unquoted covariate expression.

outcome.model

Outcome model family.

method

Mediation method label.

weights

Optional unquoted weights expression or numeric vector.

output

One of “summary” or “models”.

…

Additional arguments forwarded to mediate().

Details

Mediation currently relies on the suggested {mediation} package.

Supported outcome-model families:

  • “lm” for continuous outcomes

  • “glm” for binary outcomes

Survival mediation is not implemented yet.

Value

  • “summary” returns a PolyGeniusAssociations object.

  • “models” returns a named list of fitted objects.

See Also

associate, PolyGeniusAssociations